MIS416 A New Drug For Secondary Progressive MS
MIS416 a new drug for Secondary Progressive MS. It stimulates a range of responses in the immune system and it is being tested to find out if it is an effective treatment for SPMS. The drug is based on teenage acne bacteria; it can fill an adolescent with anxiety over a face full of blemishes. MIS416 is a new experimental medication in Phase 2B clinical trial studies for SPMS.
It is a microparticle derived from bacteria, combined with two immune-modifying molecules. It acts to stimulate a specific range of responses in the immune system.
MS is damage to the myelin sheath
If you have SPMS then the myelin sheath protecting the nerve fibers inside the CNS is damaged by a likely combination of both autoimmune and neuro degenerative processes
- This triggers inflammatory pathology that causes further damage
- In early disease, myelin is fully or partially repaired
- Over time, scar-like plaque builds up around damaged axons inhibiting repair
Take a look at the video
Here is a video of two MS sufferers who have received MIS416
Phase 2B Study
The drug is being tested for its ‘Safety and Efficacy’. Presently recruitment is underway in Australia and New Zealand. Click on Australian arm of the trial to find out more information
Almost 100 patients will be part of a trial to test the drug’s effectiveness in treating the more advanced form of MS. MIS416 is given by weekly infusion. It was shown that symptoms in patients treated in earlier studies have been reduced. Researchers believe a single dose can reduce MS disease severity and regular doses will continue the improvement. The results of this trial are expected in Autumn 2016.
What is MIS416
This bit is for the medical geeks of this world. MIS416 is a highly purified microparticle derived from the naturally occurring bacteria P. acnes
- MIS416 reliably, safely, and uniquely targets myeloid cells
- MIS416 targeted myeloid cells: – Increase in number – switch activity from pathogenic to reparative – traffic into the CNS (past the blood brain barrier) MIS416 2.0 x 0.5 micron rod shaped microparticle Introducing MIS416 – a MYELOID targeting immune modulator
- The targeted cells have an anti-inflammatory effect inside the CNS and have also been shown to: – support myelin repair by clearing myelin debris – secrete important tropic factors that can directly promote neuronal survival and axon regeneration
There is still a long way to go before this drug could be prescribed to SPMS sufferers and it does not work for everyone. This trial and MS Smart trial seem to be the only possibilities on the horizon at the moment for people with SPMS who do not have any relapses.